{"id":1483,"date":"2026-10-05T10:47:52","date_gmt":"2026-10-05T02:47:52","guid":{"rendered":"https:\/\/extruder-lab.com\/?p=1483"},"modified":"2026-10-10T15:28:29","modified_gmt":"2026-10-10T07:28:29","slug":"htgd-series-hot-melt-extruder","status":"publish","type":"post","link":"https:\/\/extruder-lab.com\/fr\/htgd-series-hot-melt-extruder.html","title":{"rendered":"Extrudeuse \u00e0 fusion \u00e0 chaud de la s\u00e9rie HTGD \u2013 Solution pour la dispersion de solides"},"content":{"rendered":"

Lors de la 8e \u00e9dition du salon CMC-CHINA China Pharmaceutical Industry Expo, qui s'est tenue les 4 et 5 septembre 2026 au Centre international des expositions de Suzhou, Hartek Technology a pr\u00e9sent\u00e9 son extrudeuse \u00e0 double vis pour thermofusibles de qualit\u00e9 pharmaceutique de la s\u00e9rie HTGD sur le stand E-B13. L'entreprise a men\u00e9 \u00e0 bien la validation du proc\u00e9d\u00e9 d'extrusion \u00e0 chaud (HME) de la copovidone VA64 avec un principe actif (proc\u00e9d\u00e9 simul\u00e9), produisant des \u00e9chantillons limpides pr\u00e9sentant une excellente uniformit\u00e9 et d'excellents r\u00e9sultats de dissolution.<\/p>\n\n\n\n

\"HTGD<\/figure>\n\n\n\n

Pr\u00e9sentation de l'extrudeuse \u00e0 fusion \u00e0 chaud<\/strong><\/h2>\n\n\n\n

La s\u00e9rie HTGD est une extrudeuse \u00e0 double vis parall\u00e8les co-rotatives pour mat\u00e9riaux thermofusibles, sp\u00e9cialement con\u00e7ue pour les applications pharmaceutiques. La configuration de ses vis \u00e0 engr\u00e8nement assure un m\u00e9lange hautement efficace, garantissant une excellente dispersion des principes actifs et des temps de s\u00e9jour courts \u2014 des facteurs essentiels pour la production de dispersions solides de haute qualit\u00e9.<\/p>\n\n\n\n

Caract\u00e9ristiques principales<\/strong><\/h3>\n\n\n\n

Canon en deux parties :<\/em> Le f\u00fbt peut \u00eatre ouvert rapidement pour \u00eatre nettoy\u00e9, ce qui \u00e9limine les zones mortes o\u00f9 des r\u00e9sidus pourraient s'accumuler. Cette conception r\u00e9duit consid\u00e9rablement les temps de changement de production et permet de respecter les exigences strictes des BPF en mati\u00e8re de nettoyage.<\/p>\n\n\n\n

Conception modulaire de la vis :<\/em> Les \u00e9l\u00e9ments de vis sont enti\u00e8rement modulaires, ce qui permet d'ajuster avec souplesse l'ensemble de vis en fonction des diff\u00e9rents principes actifs (API) et syst\u00e8mes d'excipients. Gr\u00e2ce \u00e0 cette adaptabilit\u00e9, la s\u00e9rie HTGD convient \u00e0 un large \u00e9ventail de formulations, depuis les premi\u00e8res phases de R&D jusqu'\u00e0 la fabrication \u00e0 l'\u00e9chelle industrielle.<\/p>\n\n\n\n

Syst\u00e8me de commande avanc\u00e9 :<\/em> L'installation est \u00e9quip\u00e9e d'un syst\u00e8me de commande \u00e0 automate programmable (PLC) Siemens, permettant le stockage des recettes et leur rappel d'un simple clic. Les param\u00e8tres de processus sont enti\u00e8rement tra\u00e7ables et reproductibles, ce qui garantit une qualit\u00e9 constante du produit d'un lot \u00e0 l'autre.<\/p>\n\n\n\n

Construction conforme aux BPF :<\/em> Con\u00e7us conform\u00e9ment aux principes des BPF, tous les composants entrant en contact avec le produit sont fabriqu\u00e9s en acier inoxydable de qualit\u00e9 alimentaire, ce qui garantit une facilit\u00e9 de nettoyage et d'entretien.<\/p>\n\n\n\n

\"HTGD<\/figure>\n\n\n\n

R\u00e9sultats de la validation des proc\u00e9d\u00e9s<\/strong><\/h3>\n\n\n\n

Lors de la validation sur site, le Extrudeuse \u00e0 fusion \u00e0 chaud HTGD<\/a><\/strong> Cette s\u00e9rie d'essais a permis de m\u00e9langer de mani\u00e8re homog\u00e8ne le VA64 avec un excipient simul\u00e9 par l'API, ce qui a donn\u00e9 un \u00e9chantillon uniform\u00e9ment transparent, sans s\u00e9paration de phases ni pr\u00e9cipitation. Ces r\u00e9sultats ont d\u00e9montr\u00e9 la stabilit\u00e9 du processus de l'\u00e9quipement dans la pr\u00e9paration de dispersions solides, ainsi que ses performances en mati\u00e8re de pr\u00e9cision du contr\u00f4le de la temp\u00e9rature et de facilit\u00e9 d'utilisation.<\/p>\n\n\n\n

\u00c0 propos de Hartek Technology<\/strong><\/h2>\n\n\n\n

Hartek Technology est une entreprise nationale de haute technologie d\u00e9tenant plus de 30 brevets nationaux et certifi\u00e9e conforme aux normes ISO 9001 et CE de l'Union europ\u00e9enne. Ses activit\u00e9s s'\u00e9tendent \u00e0 huit secteurs majeurs : l'emballage, l'agriculture, l'industrie, l'agroalimentaire, le tabac, la sant\u00e9, les mat\u00e9riaux sp\u00e9cialis\u00e9s et l'\u00e9lectronique li\u00e9e aux \u00e9nergies nouvelles.<\/p>","protected":false},"excerpt":{"rendered":"

At the 8th CMC-CHINA China Pharmaceutical Industry Expo, held from September 4 to 5, 2026, at the Suzhou International Expo Center, Hartek Technology showcased its HTGD series pharmaceutical-grade twin-screw hot-melt extruder at booth E-B13. The company successfully completed a hot-melt extrusion (HME) process validation of copovidone VA64 with an API (simulated process), producing crystal-clear samples […]<\/p>\n","protected":false},"author":2,"featured_media":1484,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[11],"tags":[45],"class_list":["post-1483","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-product-introduction","tag-hot-melt-extruder"],"_links":{"self":[{"href":"https:\/\/extruder-lab.com\/fr\/wp-json\/wp\/v2\/posts\/1483","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/extruder-lab.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/extruder-lab.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/extruder-lab.com\/fr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/extruder-lab.com\/fr\/wp-json\/wp\/v2\/comments?post=1483"}],"version-history":[{"count":6,"href":"https:\/\/extruder-lab.com\/fr\/wp-json\/wp\/v2\/posts\/1483\/revisions"}],"predecessor-version":[{"id":1512,"href":"https:\/\/extruder-lab.com\/fr\/wp-json\/wp\/v2\/posts\/1483\/revisions\/1512"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/extruder-lab.com\/fr\/wp-json\/wp\/v2\/media\/1484"}],"wp:attachment":[{"href":"https:\/\/extruder-lab.com\/fr\/wp-json\/wp\/v2\/media?parent=1483"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/extruder-lab.com\/fr\/wp-json\/wp\/v2\/categories?post=1483"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/extruder-lab.com\/fr\/wp-json\/wp\/v2\/tags?post=1483"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}